Starting from Perugia, where Signorelli was commissioned to paint the Saint Onuphrius’ Altarpiece (today kept in the Chapter Museum of the Cathedral of San Lorenzo) (1484), the itinerary goes to Città di Castello, where a Majesty among Saints (1474) is in the Municipal Art Gallery.
In the same gallery, there are the beautiful Martyrdom of Saint Sebastian (1498) and the Processional Banner with the Baptism of Christ and Saint John the Baptist dating back to the early 16th century. In the village of Morra, not far from Città di Castello, in the small Oratory of San Crescentino, Signorelli painted a cycle of frescoes inspired by the Passion of Christ (1507). In Citerna, the fresco depicting the Virgin and Child between Saints Michael the Archangel and Francis is in the Church of San Francesco. In the church of Santa Croce in Umbertide, today the seat of the Museum of Santa Croce, Signorelli painted a Deposition (1516),
exceptionally still provided with the original predella and frame.
The masterpiece in Umbria is undoubtedly the splendid decoration of the New Chapel of San Brizio in the right transept of the Cathedral of Santa Maria Assunta in Orvieto, painted from 1499 to 1504. Signorelli had been commissioned to finish the decoration of the vault, begun about fifty years earlier by Beato Angelico, and to carry out that of the entire chapel.
Before leaving Orvieto, at the end of this itinerary, a visit to the Museum of the Cathedral, where an oil on wood depicting Saint Mary Magdalene is kept, originally located in the chapel of Saint Brizio and dated 1504, is recommended.